In non-inflammatory locally advanced breast cancer, treatment typically includes neoadjuvant chemotherapy, surgery, and radiation therapy. Neoadjuvant chemotherapy allows in vivo assessment of primary tumor response to chemotherapy and is achieved the early control of micrometastatic disease. It also significantly improves surgical outcomes.
Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.
An approach to the management of locally advanced breast cancer: Part 1. Locally advanced breast cancer LABC comprises a heterogeneous group of diseases. SEER data demonstrate a median survival of 4.
Improved response to NAC correlates with better survival outcomes. The dual purpose of this study is to report recurrence and survival outcomes for LABC patients treated with NAC, surgery and adjuvant radiotherapy and to correlate these outcomes with tumour response after NAC using multiple response assessment methods. All LABC patients treated for curative intent with NAC, surgery, and adjuvant radiotherapy at our institute between January and December were included for analysis. Survival curves were generated by the Kaplan-Meier method and compared using the log-rank test.
The treatment of LABC has evolved from single modality treatment, consisting of radical mutilating surgery or higher doses of radiotherapy in inoperable disease to multimodality management, which along with the above two included systemic therapy. NACT was initiated to institute systemic therapy upfront at the earliest in this group of patients with a high risk of micrometastasis burden. While NACT did not yield a survival advantage, it has however made breast conservation possible in selected group of cases.
Click on image for details. Locally advanced breast cancer: Prevention is better than cure! Top cited articles.
Purpose: The aim of this study is to evaluate the prognostic factors of the group who received neoadjuvant chemotherapy with a taxane-anthracycline combination regimen. Methods: We retrospectively analyzed for locally advanced breast cancer patients who received neoadjuvant chemotherapy with adjuvant extension with taxane-anthracycline combination regimen. After curative surgery, adjuvant chemotherapy with the same regimen was performed.
Locally advanced breast cancer is invasive breast cancer that has one or more of the following features:. However, there are no signs that the cancer has spread beyond the breast region or to other parts of the body. The treatment that your doctors recommend will depend on the type of cancer you have, how advanced it is, and other personal factors.
Locally advanced breast cancer is breast cancer that has spread beyond the breast to the chest wall or the skin of the breast, or to many lymph nodes in the underarm area axillary lymph nodes. Locally advanced breast cancer has not spread to other organs. Locally advanced breast cancer is treated with a combination of chemotherapysurgery and radiation therapy.